Ligand Binding Assay:Article Title: Halogen-Aromatic π Interactions Modulate Inhibitor Residence Times.
Article Snippet: .. [7] An example for the influence of water molecules on ligand binding kinetics is the type I CDK inhibitor roniciclib, whose [*] C. Heroven, Prof. P. Brennan, F. Wolfreys, A. Chaikuad, Prof. Dr. S. Knapp Nuffield Department of Clinical Medicine Structural Genomics Consortium University of Oxford, Oxford, OX3 7DQ (UK) V. Georgi, A. E. Fern#ndez-Montalv#n Bayer AG, Drug Discovery Pharmaceuticals, Lead Discovery Berlin 13353 Berlin (Germany) A. Chaikuad, Prof. Dr. S. Knapp Buchmann Institute for Molecular Life Sciences Johann Wolfgang Goethe-University 60438 Frankfurt am Main (Germany) and Institute for Pharmaceutical Chemistry Johann Wolfgang Goethe-University 60438 Frankfurt am Main (Germany) E-mail: chaikuad@pharmchem.uni-frankfurt.de knapp@pharmchem.uni-frankfurt.de G. K. Ganotra, Prof. Dr. R. C. Wade Molecular and Cellular Modeling Group Heidelberg Institute for Theoretical Studies (HITS) 69118 Heidelberg (Germany) G. K. Ganotra Heidelberg Graduate School of Mathematical and Computational Methods for the Sciences Heidelberg University, 69120 Heidelberg (Germany) Prof. P. Brennan, F. Wolfreys Target Discovery Institute Nuffield Department of Clinical Medicine University of Oxford, Oxford, OX3 7FZ (UK) Prof. Dr. S. Knapp German Cancer Network (DKTK), Frankfurt/Mainz site 60438 Frankfurt am Main (Germany) Prof. Dr. R. C. Wade Zentrum ffr Molekulare Biologie der Universit-t Heidelberg DKFZ-ZMBH Alliance, Heidelberg University 69120 Heidelberg (Germany) Prof. Dr. R. C. Wade Interdisciplinary Center for Scientific Computing Heidelberg University, 69120 Heidelberg (Germany) Supporting information and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.org/10.1002/anie.201801666. .. 7220 T 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Angew.
Drug discovery:Article Title: Halogen-Aromatic π Interactions Modulate Inhibitor Residence Times.
Article Snippet: .. [7] An example for the influence of water molecules on ligand binding kinetics is the type I CDK inhibitor roniciclib, whose [*] C. Heroven, Prof. P. Brennan, F. Wolfreys, A. Chaikuad, Prof. Dr. S. Knapp Nuffield Department of Clinical Medicine Structural Genomics Consortium University of Oxford, Oxford, OX3 7DQ (UK) V. Georgi, A. E. Fern#ndez-Montalv#n Bayer AG, Drug Discovery Pharmaceuticals, Lead Discovery Berlin 13353 Berlin (Germany) A. Chaikuad, Prof. Dr. S. Knapp Buchmann Institute for Molecular Life Sciences Johann Wolfgang Goethe-University 60438 Frankfurt am Main (Germany) and Institute for Pharmaceutical Chemistry Johann Wolfgang Goethe-University 60438 Frankfurt am Main (Germany) E-mail: chaikuad@pharmchem.uni-frankfurt.de knapp@pharmchem.uni-frankfurt.de G. K. Ganotra, Prof. Dr. R. C. Wade Molecular and Cellular Modeling Group Heidelberg Institute for Theoretical Studies (HITS) 69118 Heidelberg (Germany) G. K. Ganotra Heidelberg Graduate School of Mathematical and Computational Methods for the Sciences Heidelberg University, 69120 Heidelberg (Germany) Prof. P. Brennan, F. Wolfreys Target Discovery Institute Nuffield Department of Clinical Medicine University of Oxford, Oxford, OX3 7FZ (UK) Prof. Dr. S. Knapp German Cancer Network (DKTK), Frankfurt/Mainz site 60438 Frankfurt am Main (Germany) Prof. Dr. R. C. Wade Zentrum ffr Molekulare Biologie der Universit-t Heidelberg DKFZ-ZMBH Alliance, Heidelberg University 69120 Heidelberg (Germany) Prof. Dr. R. C. Wade Interdisciplinary Center for Scientific Computing Heidelberg University, 69120 Heidelberg (Germany) Supporting information and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.org/10.1002/anie.201801666. .. 7220 T 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Angew.
|
